CLICK'N CUT™ for tag-less protein purification
Universal tool to obtain tag-less proteins in a one-step affinity process. Suitable for R&D, pre-clinical, clinical and industrial manufacturing.
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Self-assembly
Building new bonds through spontaneous interactions
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SPLITTERA SPLIT INTEINS

An intein is an intervening protein domain that undergoes a unique post-translational autoprocessing event, termed protein splicing. In this spontaneous process, the intein excises itself from the host protein and, in the process, ligates together the flanking N- and C-terminal residues (exteins) to form a native peptide bond.

ZERA MICROPARTICLES

Recombinant Microparticles formation through self-assembly of ZERA peptides.

ZERA determines the accumulation of properly folded recombinant proteins in the form of Microparticles (MPs), intracellular protein body-like structures, made up of assembled oligomers of properly folded proteins. The formation of MPs is driven, in vivo, by ZERA, a family of self-assembling peptides, in fusion with the protein of interest. ZERA MPs show high resistance to protease degradation and are accumulated at high levels.

CLICK GENE

In vivo covalent reconstitution of large full-length proteins mediated by Split Inteins

SPLITTERA and ZERA platforms - other applications

Tag-less protein purification

CLICK'N CUT™

CLICK’N CUT™ is an intein-based purification technology to obtain pure, tag-less proteins.

antibody bioconjugation

click bio

CLICK BIO is an intein-based tool for site-specific antibody conjugation and for generation of different formats of bispecific antibodies.

protein modification

click bio & CY-CLICK

CLICK BIO is an intein-based tool for site-specific modification of all kinds of proteins.

CY-CLICK allows protein cyclization and generation of cyclic peptide libraries

VLPs surface decoration

click vlp

CLICK VLP is an intein-based tool for site-specific decoration of virus-like particles (VLP).

diagnostics

click DX

CLICK DX is an intein-based tool for increasing the sensitivity of IVD assays.

nucleic acid and recombinant vaccines

vacc zera

VACC ZERA is a vaccine platform based on Zera microplarticles.

BLOG

BIAT Group in BIO Europe 2022

Bio-Europe November 2–4, 2022 Virtual #bioeurope2022 #zebrafish #naturegift #inteins #clickbio #clickchemistry #antibodies #partnering View in: Biat Gruop in BioEurope 2022

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Click Gene: our technology builds on existing AVV platforms

Click-Gene: our technology builds on existing AAV platforms, which are the main viral vector technology used in #genetherapy applications. Existing AAV-based platforms have been limited by capacity, and #ZIP Solutions is responding to this challenge by enabling delivery of large genes to tissues and cells

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